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Drug ReportsHuman thrombin
Thrombin
Evicel, TachoSil, VeraSeal (thrombin) is an unknown pharmaceutical. Thrombin was first approved as Tachosil on 2004-06-08. It is used to treat hemorrhage in the USA. It has been approved in Europe to treat hemostasis and surgical hemostasis.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
therapeuticsD013812
operative surgical proceduresD013514
circulatory and respiratory physiological phenomenaD002943
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name
Status
Last Update
recothromBiologic Licensing Application2025-06-09
tachosilBiologic Licensing Application2025-02-11
thrombin humanBiologic Licensing Application2009-09-13
thrombin-jmiBiologic Licensing Application2011-06-17
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
B: Blood and blood forming organ drugs
ā€” B01: Antithrombotic agents
ā€” B01A: Antithrombotic agents
ā€” B01AE: Direct thrombin inhibitors
ā€” B02: Antihemorrhagics
ā€” B02B: Vitamin k and other hemostatics
ā€” B02BC: Local hemostatics
ā€” B02BC06: Thrombin
ā€” B02BD: Blood coagulation factors
ā€” B02BD30: Thrombin
HCPCS
Code
Description
J7168
Prothrombin complex concentrate (human), kcentra, per i.u. of factor ix activity
J7196
Injection, antithrombin recombinant, 50 i.u.
J7197
Antithrombin iii (human), per i.u.
Clinical
Clinical Trials
96 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
PhĀ 1
PhĀ 2
PhĀ 3
PhĀ 4
Other
Total
Surgical blood lossD016063ā€”ā€”ā€”ā€”1ā€”ā€”1
HemorrhageD006470MP_0001914R58ā€”ā€”1ā€”ā€”1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
PhĀ 1
PhĀ 2
PhĀ 3
PhĀ 4
Other
Total
HemostasisD006487ā€”ā€”ā€”1ā€”ā€”ā€”1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameThrombin
INNthrombin
Description
Thrombin (EC 3.4.21.5, fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, an enzyme that, in humans, is encoded by the F2 gene.
Classification
Unknown
Drug classā€”
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
>4UD9:H|Thrombin heavy chain IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISM LEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVL QVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFY THVFRLKKWIQKVIDQFGE >4UD9:I|Hirudin-2 GDFEEIPEE(TYS)LQ >4UD9:L|Prothrombin EADCGLRPLFEKKSLEDKTERELLESYI
Identifiers
PDB148D, 1A0H, 1A2C, 1A3B, 1A3E, 1A46, 1A4W, 1A5G, 1A61, 1ABI, 1ABJ, 1AD8, 1AE8, 1AFE, 1AHT, 1AI8, 1AIX, 1AVG, 1AWF, 1AWH, 1AY6, 1B5G, 1B7X, 1BA8, 1BB0, 1BBR, 1BCU, 1BHX, 1BMM, 1BMN, 1BTH, 1C1U, 1C1V, 1C1W, 1C4U, 1C4V, 1C4Y, 1C5L, 1C5N, 1C5O, 1CA8, 1D3D, 1D3P, 1D3Q, 1D3T, 1D4P, 1D6W, 1D9I, 1DE7, 1DIT, 1DLK, 1DM4, 1DOJ, 1DWB, 1DWC, 1DWD, 1DWE, 1DX5, 1E0F, 1EB1, 1EGT, 1EOJ, 1EOL, 1ETR, 1ETS, 1ETT, 1FPC, 1FPH, 1G30, 1G32, 1G37, 1GHV, 1GHW, 1GHX, 1GHY, 1GJ4, 1GJ5, 1H8D, 1H8I, 1HAG, 1HAH, 1HAI, 1HAO, 1HAP, 1HBT, 1HDT, 1HGT, 1HLT, 1HRT, 1HUT, 1HXE, 1HXF, 1ID5, 1IHS, 1IHT, 1JMO, 1JOU, 1JWT, 1K21, 1K22, 1KMA, 1KTS, 1KTT, 1KWM, 1LHC, 1LHD, 1LHE, 1LHF, 1LHG, 1MH0, 1MKW, 1MKX, 1MU6, 1MU8, 1MUE, 1NM6, 1NO9, 1NRN, 1NRO, 1NRP, 1NRQ, 1NRR, 1NRS, 1NT1, 1NU7, 1NU9, 1NY2, 1NZQ, 1O0D, 1O2G, 1OOK, 1OYT, 1P8V, 1PPB, 1PPC, 1PPH, 1QBV, 1QHR, 1QJ1, 1QJ6, 1QJ7, 1QUR, 1RD3, 1RDE, 1RIW, 1SB1, 1SFQ, 1SG8, 1SGI, 1SHH, 1SL3, 1T4U, 1T4V, 1TA2, 1TA6, 1TB6, 1TBQ, 1TBR, 1TBZ, 1THP, 1THR, 1THS, 1TMB, 1TMT, 1TMU, 1TOC, 1TOM, 1TQ0, 1TQ7, 1TWX, 1UCY, 1UMA, 1UVS, 1UVT, 1UVU, 1VIT, 1VR1, 1VZQ, 1W7G, 1WAY, 1WBG, 1XM1, 1XMN, 1YCP, 1YPE, 1YPG, 1YPJ, 1YPK, 1YPL, 1YPM, 1Z71, 1Z8I, 1Z8J, 1ZGI, 1ZGV, 1ZRB, 2A0Q, 2A1D, 2A2X, 2A45, 2AFQ, 2ANK, 2ANM, 2B5T, 2BDY, 2BVR, 2BVS, 2BVX, 2BXT, 2BXU, 2C8W, 2C8X, 2C8Y, 2C8Z, 2C90, 2C93, 2CF8, 2CF9, 2CN0, 2ERW, 2F3C, 2FEQ, 2FES, 2GDE, 2GP9, 2H9T, 2HGT, 2HNT, 2HPP, 2HPQ, 2HWL, 2IDN, 2JH0, 2JH5, 2JH6, 2OCV, 2OD3, 2ODY, 2PGB, 2PGQ, 2PKS, 2PUX, 2PV9, 2PW8, 2R2M, 2THF, 2UUF, 2UUJ, 2UUK, 2UWL, 2UWO, 2V3H, 2V3O, 2WV1, 2ZC9, 2ZDA, 2ZDV, 2ZF0, 2ZFF, 2ZFP, 2ZFQ, 2ZFR, 2ZG0, 2ZGB, 2ZGX, 2ZHE, 2ZHF, 2ZHQ, 2ZHW, 2ZI2, 2ZIQ, 2ZNK, 2ZO3, 2ZPK, 3A1M, 3B23, 3B9F, 3BEF, 3BEI, 3BF6, 3BIU, 3BIV, 3BV9, 3C1K, 3C27, 3D49, 3D4U, 3D66, 3D67, 3D68, 3DA9, 3DD2, 3DGV, 3DHK, 3DT0, 3DUX, 3EDX, 3EE0, 3EGK, 3EQ0, 3F68, 3GIC, 3GIS, 3HAT, 3HK3, 3HK6, 3HKI, 3HKJ, 3HTC, 3JZ1, 3JZ2, 3K65, 3LDX, 3LMS, 3LU9, 3OSL, 3P17, 3P6Z, 3P70, 3PMA, 3PMB, 3PMH, 3PO1, 3QDZ, 3QGN, 3QLP, 3QTO, 3QTV, 3QWC, 3QX5, 3R3G, 3RLW, 3RLY, 3RM0, 3RM2, 3RML, 3RMM, 3RMN, 3RMO, 3S69, 3S7H, 3S7K, 3SHA, 3SHC, 3SI3, 3SI4, 3SQE, 3SQH, 3SV2, 3T5F, 3TU7, 3U69, 3U8O, 3U8R, 3U8T, 3U98, 3U9A, 3UTU, 3UWJ, 3VW7, 3VXE, 3VXF, 4AX9, 4AYV, 4AYY, 4AZ2, 4BAH, 4BAK, 4BAM, 4BAN, 4BAO, 4BAQ, 4BOH, 4BTI, 4BTT, 4BTU, 4CH2, 4CH8, 4DIH, 4DII, 4DT7, 4DY7, 4E05, 4E06, 4E7N, 4E7R, 4GSO, 4H6S, 4H6T, 4HFP, 4HTC, 4HZH, 4I7Y, 4LOY, 4LXB, 4LZ1, 4LZ4, 4MLF, 4P10, 4RKJ, 4RKO, 4RN6, 4THN, 4UD9, 4UDW, 4UE7, 4UEH, 4UFD, 4UFE, 4UFF, 4UFG, 4YES, 5A2M, 5AF9, 5AFY, 5AFZ, 5AHG, 5CMX, 5DO4, 5E8E, 5EW1, 5EW2, 5GDS, 5GIM, 5HVF, 5HVG, 5HVH, 5JDU, 5JFD, 5JQN, 5JZY, 5L6N, 5LCE, 5LPD, 5MJT, 5MLS, 5MM6, 5NDD, 5NDZ, 5NHU, 5NJ6, 5TO3, 5XRF, 6CYM, 6EO6, 6EO7, 6EO8, 6EO9, 6EVV, 6FJT, 6GBW, 6GN7, 6GWE, 6HSX, 6I51, 6P9U, 6PXJ, 6PXQ, 6ROT, 6T3M, 6T3Q, 6T4A, 6T52, 6T53, 6T54, 6T55, 6T56, 6T57, 6T7H, 6T89, 6T8A, 6TDT, 6TFI, 6TKG, 6TKH, 6TKI, 6TKJ, 6TKL, 6V64, 6Y02, 6Y9H, 6YB6, 6YHG, 6YHJ, 6YMP, 6YN3, 6YQV, 6YSJ, 6YSX, 6Z48, 6Z8V, 6Z8W, 6Z8X, 6ZGO, 6ZUG, 6ZUH, 6ZUN, 6ZUU, 6ZUW, 6ZUX, 6ZV7, 6ZV8, 7A0D, 7A0E, 7A0F, 7AC9, 7KME, 7MJ5, 7NEE, 7NEU, 7NTU, 7PHX, 7SR9, 7V3T, 7ZKL, 7ZKM, 7ZKN, 7ZKO, 8ASE, 8ASF, 8BW5, 8BWW, 8EF4, 8KME
CAS-IDā€”
RxCUIā€”
ChEMBL IDCHEMBL2108110
ChEBI IDā€”
PubChem CIDā€”
DrugBankā€”
UNII ID25ADE2236L (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
No data
Trends
No data
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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225 adverse events reported
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