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Drug ReportsHuman thrombin
Thrombin
Evicel, TachoSil, VeraSeal (thrombin) is an unknown pharmaceutical. Thrombin was first approved as Tachosil on 2004-06-08. It is used to treat hemorrhage in the USA. It has been approved in Europe to treat hemostasis and surgical hemostasis.
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Target
Variants
Financial
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Events Timeline
5D
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3M
6M
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1Y
2Y
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
therapeuticsD013812
operative surgical proceduresD013514
circulatory and respiratory physiological phenomenaD002943
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name
Status
Last Update
recothromBiologic Licensing Application2024-01-04
tachosilBiologic Licensing Application2025-02-11
thrombin humanBiologic Licensing Application2009-09-13
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
B: Blood and blood forming organ drugs
B01: Antithrombotic agents
B01A: Antithrombotic agents
B01AE: Direct thrombin inhibitors
B02: Antihemorrhagics
B02B: Vitamin k and other hemostatics
B02BC: Local hemostatics
B02BC06: Thrombin
B02BD: Blood coagulation factors
B02BD30: Thrombin
HCPCS
Code
Description
J7168
Prothrombin complex concentrate (human), kcentra, per i.u. of factor ix activity
J7196
Injection, antithrombin recombinant, 50 i.u.
J7197
Antithrombin iii (human), per i.u.
Clinical
Clinical Trials
95 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HemorrhageD006470MP_0001914R581595625
Surgical blood lossD01606312137
HemostasisD00648713126
Healthy volunteers/patients4115
Wounds and injuriesD014947T14.812114
Soft tissue injuriesD017695314
ThrombosisD013927123
FibrosisD005355112
Cardiovascular surgical proceduresD01350422
Rotator cuff injuriesD000070636M75.1112
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Type 1 diabetes mellitusD003922EFO_0001359E10112
Transfusion reactionD065227D69.51112
Congenital heart defectsD006330Q24.9112
Islets of langerhans transplantationD01638111
Epidermolysis bullosaD004820Q8111
Epidermolysis bullosa dystrophicaD016108Q81.211
Hemorrhagic shockD01277111
Blood transfusionD00180311
Postoperative complicationsD01118311
Acute lung injuryD055371EFO_000461011
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Virus diseasesD014777B34112
Ebola hemorrhagic feverD019142EFO_0007243A98.411
Marburg virus diseaseD008379EFO_0007358A98.311
Muscular atrophyD00913311
RuptureD01242111
UlcerD014456MPATH_57911
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Blood coagulation disordersD001778EFO_0009314D68.955
Hemostatic disordersD02014155
ThromboembolismD01392322
Disseminated intravascular coagulationD004211D6522
Stomach neoplasmsD013274EFO_0003897C1611
AdenomaD00023611
HypertensionD006973EFO_0000537I1011
Portal hypertensionD006975EFO_0000666K76.611
Cystic fibrosisD003550EFO_0000390E8411
Hemophilia aD006467EFO_0007267D6611
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameThrombin
INNthrombin
Description
Thrombin (EC 3.4.21.5, fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, an enzyme that, in humans, is encoded by the F2 gene.
Classification
Unknown
Drug class
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
>4UD9:H|Thrombin heavy chain IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISM LEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVL QVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFY THVFRLKKWIQKVIDQFGE >4UD9:I|Hirudin-2 GDFEEIPEE(TYS)LQ >4UD9:L|Prothrombin EADCGLRPLFEKKSLEDKTERELLESYI
Identifiers
PDB148D, 1A0H, 1A2C, 1A3B, 1A3E, 1A46, 1A4W, 1A5G, 1A61, 1ABI, 1ABJ, 1AD8, 1AE8, 1AFE, 1AHT, 1AI8, 1AIX, 1AVG, 1AWF, 1AWH, 1AY6, 1B5G, 1B7X, 1BA8, 1BB0, 1BBR, 1BCU, 1BHX, 1BMM, 1BMN, 1BTH, 1C1U, 1C1V, 1C1W, 1C4U, 1C4V, 1C4Y, 1C5L, 1C5N, 1C5O, 1CA8, 1D3D, 1D3P, 1D3Q, 1D3T, 1D4P, 1D6W, 1D9I, 1DE7, 1DIT, 1DLK, 1DM4, 1DOJ, 1DWB, 1DWC, 1DWD, 1DWE, 1DX5, 1E0F, 1EB1, 1EGT, 1EOJ, 1EOL, 1ETR, 1ETS, 1ETT, 1FPC, 1FPH, 1G30, 1G32, 1G37, 1GHV, 1GHW, 1GHX, 1GHY, 1GJ4, 1GJ5, 1H8D, 1H8I, 1HAG, 1HAH, 1HAI, 1HAO, 1HAP, 1HBT, 1HDT, 1HGT, 1HLT, 1HRT, 1HUT, 1HXE, 1HXF, 1ID5, 1IHS, 1IHT, 1JMO, 1JOU, 1JWT, 1K21, 1K22, 1KMA, 1KTS, 1KTT, 1KWM, 1LHC, 1LHD, 1LHE, 1LHF, 1LHG, 1MH0, 1MKW, 1MKX, 1MU6, 1MU8, 1MUE, 1NM6, 1NO9, 1NRN, 1NRO, 1NRP, 1NRQ, 1NRR, 1NRS, 1NT1, 1NU7, 1NU9, 1NY2, 1NZQ, 1O0D, 1O2G, 1OOK, 1OYT, 1P8V, 1PPB, 1PPC, 1PPH, 1QBV, 1QHR, 1QJ1, 1QJ6, 1QJ7, 1QUR, 1RD3, 1RDE, 1RIW, 1SB1, 1SFQ, 1SG8, 1SGI, 1SHH, 1SL3, 1T4U, 1T4V, 1TA2, 1TA6, 1TB6, 1TBQ, 1TBR, 1TBZ, 1THP, 1THR, 1THS, 1TMB, 1TMT, 1TMU, 1TOC, 1TOM, 1TQ0, 1TQ7, 1TWX, 1UCY, 1UMA, 1UVS, 1UVT, 1UVU, 1VIT, 1VR1, 1VZQ, 1W7G, 1WAY, 1WBG, 1XM1, 1XMN, 1YCP, 1YPE, 1YPG, 1YPJ, 1YPK, 1YPL, 1YPM, 1Z71, 1Z8I, 1Z8J, 1ZGI, 1ZGV, 1ZRB, 2A0Q, 2A1D, 2A2X, 2A45, 2AFQ, 2ANK, 2ANM, 2B5T, 2BDY, 2BVR, 2BVS, 2BVX, 2BXT, 2BXU, 2C8W, 2C8X, 2C8Y, 2C8Z, 2C90, 2C93, 2CF8, 2CF9, 2CN0, 2ERW, 2F3C, 2FEQ, 2FES, 2GDE, 2GP9, 2H9T, 2HGT, 2HNT, 2HPP, 2HPQ, 2HWL, 2IDN, 2JH0, 2JH5, 2JH6, 2OCV, 2OD3, 2ODY, 2PGB, 2PGQ, 2PKS, 2PUX, 2PV9, 2PW8, 2R2M, 2THF, 2UUF, 2UUJ, 2UUK, 2UWL, 2UWO, 2V3H, 2V3O, 2WV1, 2ZC9, 2ZDA, 2ZDV, 2ZF0, 2ZFF, 2ZFP, 2ZFQ, 2ZFR, 2ZG0, 2ZGB, 2ZGX, 2ZHE, 2ZHF, 2ZHQ, 2ZHW, 2ZI2, 2ZIQ, 2ZNK, 2ZO3, 2ZPK, 3A1M, 3B23, 3B9F, 3BEF, 3BEI, 3BF6, 3BIU, 3BIV, 3BV9, 3C1K, 3C27, 3D49, 3D4U, 3D66, 3D67, 3D68, 3DA9, 3DD2, 3DGV, 3DHK, 3DT0, 3DUX, 3EDX, 3EE0, 3EGK, 3EQ0, 3F68, 3GIC, 3GIS, 3HAT, 3HK3, 3HK6, 3HKI, 3HKJ, 3HTC, 3JZ1, 3JZ2, 3K65, 3LDX, 3LMS, 3LU9, 3OSL, 3P17, 3P6Z, 3P70, 3PMA, 3PMB, 3PMH, 3PO1, 3QDZ, 3QGN, 3QLP, 3QTO, 3QTV, 3QWC, 3QX5, 3R3G, 3RLW, 3RLY, 3RM0, 3RM2, 3RML, 3RMM, 3RMN, 3RMO, 3S69, 3S7H, 3S7K, 3SHA, 3SHC, 3SI3, 3SI4, 3SQE, 3SQH, 3SV2, 3T5F, 3TU7, 3U69, 3U8O, 3U8R, 3U8T, 3U98, 3U9A, 3UTU, 3UWJ, 3VW7, 3VXE, 3VXF, 4AX9, 4AYV, 4AYY, 4AZ2, 4BAH, 4BAK, 4BAM, 4BAN, 4BAO, 4BAQ, 4BOH, 4BTI, 4BTT, 4BTU, 4CH2, 4CH8, 4DIH, 4DII, 4DT7, 4DY7, 4E05, 4E06, 4E7N, 4E7R, 4GSO, 4H6S, 4H6T, 4HFP, 4HTC, 4HZH, 4I7Y, 4LOY, 4LXB, 4LZ1, 4LZ4, 4MLF, 4P10, 4RKJ, 4RKO, 4RN6, 4THN, 4UD9, 4UDW, 4UE7, 4UEH, 4UFD, 4UFE, 4UFF, 4UFG, 4YES, 5A2M, 5AF9, 5AFY, 5AFZ, 5AHG, 5CMX, 5DO4, 5E8E, 5EW1, 5EW2, 5GDS, 5GIM, 5HVF, 5HVG, 5HVH, 5JDU, 5JFD, 5JQN, 5JZY, 5L6N, 5LCE, 5LPD, 5MJT, 5MLS, 5MM6, 5NDD, 5NDZ, 5NHU, 5NJ6, 5TO3, 5XRF, 6CYM, 6EO6, 6EO7, 6EO8, 6EO9, 6EVV, 6FJT, 6GBW, 6GN7, 6GWE, 6HSX, 6I51, 6P9U, 6PXJ, 6PXQ, 6ROT, 6T3M, 6T3Q, 6T4A, 6T52, 6T53, 6T54, 6T55, 6T56, 6T57, 6T7H, 6T89, 6T8A, 6TDT, 6TFI, 6TKG, 6TKH, 6TKI, 6TKJ, 6TKL, 6V64, 6Y02, 6Y9H, 6YB6, 6YHG, 6YHJ, 6YMP, 6YN3, 6YQV, 6YSJ, 6YSX, 6Z48, 6Z8V, 6Z8W, 6Z8X, 6ZGO, 6ZUG, 6ZUH, 6ZUN, 6ZUU, 6ZUW, 6ZUX, 6ZV7, 6ZV8, 7A0D, 7A0E, 7A0F, 7AC9, 7KME, 7MJ5, 7NEE, 7NEU, 7NTU, 7PHX, 7SR9, 7V3T, 7ZKL, 7ZKM, 7ZKN, 7ZKO, 8ASE, 8ASF, 8BW5, 8BWW, 8EF4, 8KME
CAS-ID
RxCUI
ChEMBL IDCHEMBL2108110
ChEBI ID
PubChem CID
DrugBank
UNII ID25ADE2236L (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
No data
Trends
No data
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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225 adverse events reported
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